Because of the substantial influence of the ALDH2 locus, genome-wide association analysis (GWA) was rerun for flushing response with rs671 genotype included as a covariate to increase power to detect other previously unknown risk variants. In addition to the GWA analysis, SNPs previously associated (genome-wide p < 5×10-7) with AD, maximum drinks or other drinking behavior in European-derived populations (Treutlein et al. 2006; Treutlein & Cichon, 2009; Heath et al. 2011; Schumann et al. 2011) and/or East Asian populations (Wang et al. 2008; Takeuchi et al. 2011; Wang et al. 2012; Chen et al. 2012) were examined for association in this sample.
