We consider the components of the MEA recording and stimulation system diagram as shown in Figure 6: (A) the conductive extracellular volume where the electric field caused by neural signal sources forms; (B) the substrate with the embedded microelectrodes; and (C) the hardware connected to the electrodes, including amplifiers, filters, digitizer, data transmission, and stimulator (Stett et al., 2003; Fejtl et al., 2006).
