We interrogated all HLC- and iPSC-specific eGenes as determined by meta-analysis for enrichment of functional pathways or gene sets using ToppGene (Chen et al., 2009). Default parameters were used at a multi-testing correction threshold of Benjamini-Hochberg FDR < 5% and maximum of 2000 genes per set. We used 267 HLC-specific eGenes and 473 iPSC-specific eGenes for pathway analyses with the ToppFun tool implemented in the ToppGene Suite. A total of 19 HLC-specific eGenes and 52 iPSC-specific eGenes were excluded due to lack of matching IDs in the ToppFun database, leaving 248 HLC-specific and 421 iPSC-specific eGenes.
