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Chunk #58 — Materials and Methods — There were three phases to this study — Heritability of phenotypic traits; genetic correlation between traits

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Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP.
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SOLAR version 4.0.7 was used to fit a variance components model for estimating heritability. In SOLAR, maximum likelihood estimation is applied to a mixed-effects model that includes fixed covariate effects, additive genetic effects and residual error. Heritability is calculated as the proportion of phenotypic variance explained by additive genetic effects while accounting for covariates. Z scores were computed for the log10 EEG power variables. Age was a significant covariate for alpha power at all leads contributing between 0.009 (O1) to 0.035 of the variance at PZ. After transformation by Z scores and covariate adjustment for age and sex the residual kurtosis was normal for alpha power but slightly elevated (>0.5) for theta (approximately 1 for all leads except O1 (2.2)) and for beta (0.8–1.0). The high kurtosis (2.2) for theta power at O1 was corrected by inverse normalization using SOLAR version 4.1.0.