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Chunk #0 — Introduction

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Fluctuating disinhibition: implications for the understanding and treatment of alcohol and other substance use disorders.
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The constructs of impulsivity and (poor) executive functioning are central to substance use disorders and other addictive behaviors (1). These constructs are multifaceted and consist of subcomponents which include sensitivity to reward, preference for immediate gratification, risk taking, and disinhibition (2). Disinhibition is defined as the inability to suppress, delay, or change a response that is no longer required or is inappropriate. This inability to control behavior can be measured in the laboratory using computer tasks, such as the Stop Signal (3) and Go/No-Go (4) tasks, both of which require participants to inhibit a dominant motor response. The (in)ability to control oculomotor reflexes is another index of disinhibition: for example, the anti-saccade and delayed ocular return tasks require individuals to suppress or delay reflexive saccades to visual stimuli (5, 6).