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Chunk #4 — Results — Nonparametric linkage analysis

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Whole-genome linkage analysis in mapping alcoholism genes using single-nucleotide polymorphisms and microsatellites.
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The results from the whole-genome scans using the microsatellites and the SNPs had good overall concordance. Six regions showed some evidence of increased allele sharing, with a NPL cutoff value of 2 for either the SNP scan, the microsatellite scan, or both. The results were summarized in Table 1, which also included analyses containing erroneous genotypes. Overall, the scan using the SNPs gave stronger linkage signals than those using the microsatellites. Except for two regions on chromosomes 2 and 13 that showed significant linkage evidence using the microsatellites but not using the SNPs (there was no SNP genotyped in the region on chromosome 13), the SNP scan gave stronger linkage signal. Four regions on chromosomes 1, 2, 12, and 13 showed significant linkage evidence when using the SNPs but not using the microsatellites. Both the SNP and the microsatellite scans indicated strong linkage signals on chromosome 7, and relatively strong linkage signals on chromosome 2. Results for these two chromosomes (excluding the erroneous genotypes) and one-LOD confidence intervals of these peaks are shown in Figure 1. In general, the peaks