The ability to remember is likely the most significant and distinctive feature of our existence. We are largely defined by what we have learned and what we can remember. Conversely, impairments in the ability to remember can lead to devastating memory losses, that are the hallmark of several neurodegenerative disorders [1] and alcohol use disorders (AUD; [2]). Learning may be described as the mechanism by which new information about the individual’s environment is acquired, and memory as the mechanism by which that knowledge is retained [3]. Storage of memories in the brain almost certainly involves some form of synaptic modifications. Ramón y Cajal originally hypothesized that information storage relies on the changes in the strength of synaptic connections between connected pairs of neurons [4]. The guiding principle for such neuronal interactions was later proposed by Donald Hebb in his book, ‘The Organization of Behavior’ [5], where he states “When an axon of cell A is near enough to excite cell B or repeatedly or consistently takes part in firing it, some growth or metabolic changes takes place in one or
