In the multinomial regression with relatives’ AUD remission status as the outcome, adjusted for all covariates, the interaction between probands’ abstinent remission and the variable representing related pairs (versus unrelated pairs) was significant (relative risk ratio (RRR)=4.37, 95% confidence interval (CI)=1.62–11.79, p=.004) and therefore the regressions were calculated separately in related and unrelated pairs (Table 3, full results available in Supplemental Table 1). In related pairs, individuals with an abstinent proband were more than 3 times as likely to be abstinent themselves when compared to individuals related to a proband with persistent AUD (relative risk ratio=3.27, 95% CI=1.56–6.85, p=.002); this association was not significant in unrelated pairs. No other significant associations of probands’ with relatives’ AUD remission status were observed.
