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Chunk #22 — Discussion

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Sibling comparisons elucidate the associations between educational attainment polygenic scores and alcohol, nicotine and cannabis.
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Third, because genetic associations can differ across ancestral groups, we focused here on the European ancestry subset of COGA because the discovery GWAS for educational attainment used a European ancestry sample. It is unknown whether the same pattern of effects would be observed in samples of non-European ancestry.