impaired mitochondrial biogenesis in cardiac cells and increase the susceptibility/severity of an MI event. On the other hand, excessive sustained elevation of CTRP3 may also be detrimental to cardiovascular health as CTRP3 as promotes vascular and aortic ring calcification (90). Increase vascular calcification promotes arterial hardening and the development of arteriosclerosis. Regardless the associations between CTRP3-mediated signaling and CVD appear promising and need to be investigated in more detail.
