Aβ phagocytosis [127] and similar data have been obtained for IL-10 [129]. This effect also extends to degradation of the internalized Aβ. Treatment with IL-4 or macrophage colony-stimulating factor can lower the pH of the phagosome and lysosome and allow for more efficient degradation of Aβ [130,131]. These in-vitro M1 versus M2 observations are further supported by an ever-increasing set of in-vivo data, as detailed next.
