Treatment of patients with substance abuse disorder by neurofeedback may become more complicated when patients present various psychiatric conditions. When addiction is comorbid with ADHD it is suggested that SMR (or beta increase, theta decrease) training should be conducted to address the related ADHD disorder first (Biederman et al. 1997). Applicability of neurofeedback methods to treat anxiety and affective disorders is reviewed by Hammond (2006). Peniston and Kulkosky (1990) describe personality normalization in alcoholics treated with EEG biofeedback. Alpha-theta feedback has also been reported as efficacious in alcoholics with depressive symptoms (Saxby and Peniston 1995). There are only a few case studies on the efficacy of neurofeedback for treating generalized anxiety disorder (Vanathy et al. 1998) and PTSD (Huang-Storms et al. 2006; Graap et al. 1997). Alpha-theta feedback has been described as efficacious in post-combat PTSD (Peniston and Kulkosky 1991; Peniston et al. 1993). However, additional research needs to be completed to determine the clinical outcome and efficacy of bio-behavioral treatment based on brain wave self-regulation in addiction disorders that are comorbid with various anxiety disorders and PTSD.