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Chunk #31 — METHODS — Genotyping and quality control

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Identification of ten loci associated with height highlights new biological pathways in human growth.
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the specific design of this DNA panel (near-ends of the height distribution) but also because effect sizes on height are small (and were inflated by the winner’s curse in the meta-analysis), we promoted for genotyping in larger follow-up cohorts markers that had an odds ratio consistent with the direction of the effect observed in the meta-analysis (without considering the magnitude of the European American CMH P values). For the FINRISK97 panel, 29 SNPs were attempted and two failed. For the PPP panel, 23 SNPs were attempted and two failed. For the FUSION stage 2 panel, 27 SNPs were attempted and one failed. For the KORA S4 panel, five SNPs were attempted and one failed. For all passing SNPs, the genotyping success rate was >96% and the consensus error rate, estimated from replicates, was <0.1%.