Chunk #215 — VII. Classes of genes that are identified in multiple GWA samples for multiple phenotypes: Focus on cell adhesion related genes

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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These data thus provide convergent results from searches for drug- regulated genes and from association-based genome scans for drug abuse vulnerability alleles. The data support the idea that NrCAM and NRXN3 haplotypes contribute to human individual differences in addiction vulnerability in ways that are likely to depend on differences in levels of NrCAM expression and/or regulation and NRXN3 splicing.