Heavy alcohol use during adolescence is similarly associated with smaller prefrontal WM volumes (De Bellis et al., 2005; Medina et al., 2008). Increased anisotropy in the genu and isthmus of the corpus callosum in alcohol-using teens lends further support to atypical developmental trajectories (De Bellis et al., 2008). Correlates of these changes are seen in attenuated frontal response during spatial working memory (Tapert et al., 2001; Tapert et al., 2004) and deficits on neuropsychological measures of attention, memory retrieval, and visuospatial functioning (Brown et al., 2000; Tapert & Brown, 1999, 2000; Tapert et al., 2002).
