Chunk #10 — Results — The extent of D1/D2 MSN dendritic arborization is unaffected by 6-OHDA lesion, in contrast to that of D1 and D2 MSNs

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Striatal Neurons Expressing D and D Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice.

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Statistical comparison between sham and 6-OHDA-lesioned mice in regard to the extent of somatodendritic domain belonging to the D1, D2 and D1/D2 MSNs in the dorsal striatum indicates that the total dendritic length of the D1 MSNs was reduced in the DA-depleted striatum by 60% (0.60 ± 0.04 vs. 1.48 ± 0.13 mm, P < 0.0001, Fig. 6a) and by 28% for the D2 MSNs (0.78 ± 0.09 vs. 1.08 ± 0.08 mm, P = 0.0191, Fig. 6b). Surprisingly, no significant differences between sham and 6-OHDA-lesioned mice were observed regarding the total dendritic length of the D1/D2 MSNs (0.61 ± 0.05 vs. 0.75 ± 0.07 mm, P = 0.6356, Fig. 6c). Accordingly, in 6-OHDA-lesioned mice, a lower number of dendritic branching points were observed for the D1 MSNs (8.7 ± 0.7 vs. 16.6 ± 1.5 branching points, P < 0.0001) and the D2 MSNs (10.7 ± 0.9 vs. 15.0 ± 1.4 branching points, P = 0.0120) but not for the D1/D2 MSNs with 9.5 ± 0.8 branching points in both experimental groups (P > 0.9999).