influences captured in this PRS will likely predict cannabis use behavior in AA samples poorly44. Therefore, the current manuscript focuses on COGA’s EA participants. However, COGA includes one of the largest genetically informative AA samples available. We therefore conducted a series of exploratory analyses in 3359 AA participants to test the predictive power of EA-based summary statistics in an AA population (Supplementary Table 2). Secondary analyses conducted in the AA participants followed the same procedures as described for EA participants. We calculated a series of scores in our sample that included SNPs meeting increasingly stringent p value thresholds (p < 0.0001, p < 0.001, p < 0.01, p < 0.05, p < 0.10, p < 0.20, p < 0.30, p < 0.40, p < 0.50) in the discovery GWAS.
