etc.), making it potentially less powerful than a homogeneous phenotype. We note that the number of SNPs for which data were available for some cell lines/tissue types limited our analyses examining the localization of implicated SNPs to genomic regions of regulatory relevance. In addition, previous work suggests that there is substantial overlap in regulatory regions across tissues [41], so “tissue-specific” findings should be interpreted with caution. Finally, the exploration of epistatic interactions, gene-environment interactions, or main effects of environmental risk factors on alcohol problems were beyond the scope of this study.
