Several genomic regions have been implicated in linkage studies30 and, recently, replicated evidence implicating specific genes has been reported. Increasing evidence suggests an overlap in genetic susceptibility with schizophrenia, a psychotic disorder with many similarities to BD. In particular association findings have been reported with both disorders at DAOA (d-amino acid oxidase activator), DISC1 (disrupted in schizophrenia 1), NRG1 (neuregulin1) and DTNBP1 (dystrobrevin binding protein 1)31.
