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Chunk #32 — Discussion — Strength and weaknesses

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Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study.
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Subcohort participants were shown to be representative of EPIC participants eligible for inclusion in InterAct within each country, and thus provide an excellent opportunity for data sharing with research groups studying other disease outcomes within EPIC. Sensitivity analyses calculating hazard ratios from unweighted Cox regression using full EPIC cohort data compared to weighted Cox regression using case-subcohort data showed that results were comparable for sex, but differed somewhat for age.