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Chunk #25 — RESULTS — Convergence of Common and Rare Variant Associations

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Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
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DD; a transcriptional regulator (BCL11B), the well-known CACNA1C38, and genes mentioned elsewhere in this paper (GRIN2A and SLC39A8). Genes encoding additional transcriptional regulators are also of note; RERE, FOXP1 and MYT1L. RERE was prioritised by SMR and is associated with DD. FOXP1 and MYT1L are associated with both DD and ASD and met our fine-mapping prioritisation criteria in the core PGC dataset (Supplementary Table 12).