With many functional domains, the different Kalirin isoforms are capable of integrating inputs from a variety of surface molecules (ephrins, N-cadherin, Trk receptors), phosphatidylinositides, cytoskeletal components, PDZ domain proteins like spinophilin and PSD-95, plus signaling molecules and growth factors [18,22-25]. Kal7 is also crucial for the expression of normal long-term potentiation in CA1 hippocampal pyramidal neurons [17].
