associated with reduced adiposity and hypolipidemia [67]. In addition, circulating levels of norepinephrine is elevated in these animals, indicating increased sympathetic nervous system activity, which explains, at least in part, the defects in the energy metabolism [76]. On the other hand, adipocyte-autonomous factors appear less likely to be involved in these phenotypes, because XLαs is not expressed in the adipocytes of adult wild-type mice [76].
