alcohol use and its downstream consequences [Holmes and others 2014; Silverwood and others 2014]. However, recent findings have shown that ADH1B may affect the human phenome through alcohol-independent mechanisms also [Polimanti and others 2016a]. To understand the network of ADH1B activities and consequences, we provide here a bioinformatic analysis of gene regulation and the molecular functions of its protein product, a literature review of the studies conducted on this gene, and a discussion of future perspectives of ADH1B research. It is our intention to help scientists who are interested in the ADH1B locus to connect multiple functional aspects that they should might consider in their research.
