overlap among the GENOA, PGC-SUD, and MVP-SAGE-YP analyses, we were able to combine the samples and increase substantially available sample size compared to standard meta-analysis. Follow-up analyses included: (1) evaluation of genetic correlation with brain-related phenotypes; (2) estimation of predicted genetically driven differential expression in brain tissues; (3) colocalization of genetic association loci with cis-eQTLs; (4) evaluation of loci pleiotropy, and (5) druggability of nominated targets.
