brief, we determined which of the mapped genes was most resistant (i.e. robust) to a change in the number of strains used for the genetic mapping. Of note, 13 of the 15 genes that were most robustly associated with OIH, were the genes that were most strongly associated with the initial analysis of the OIH response (Table 2). However, the robustness analysis significantly altered the gene order. The deleted in colorectal carcinoma (Dcc) gene was the highest ranked gene by the robustness analysis. Studies have linked this gene to behavioral effects of acute and repeated exposure to stimulant drugs of abuse, cognitive flexibility, learning and memory, and movement disorders [21–25].
