by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway (http://www.genome.ad.jp/kegg/), which is a knowledge base linking a set of genes with a network of interacting molecules in the cells [27]. We used the WebGestalt tool to test significant KEGG pathways. Microarray data are MIAME compliant and the raw data have been deposited in a MIAME compliant database (Gene Expression Omnibus, accession number GSE33565).