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Chunk #27 — RESULTS — Explaining phenotypic variation

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Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
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Table 4 shows the results for individual SNPs as well as for all SNPs included together in the model. In EAs, the three SNPs on chromosome 15q25 together give an R2 of 1.87%; in AAs, the three SNPs give a very similar R2 of 1.85%. In EAs, rs16969968 has the highest individual R2 of the SNPs considered (1.4%). In AAs, rs16969968 has a similar individual R2 of 1.3%, but there are two other SNPs with higher R2 in AAs: rs6494212 in CHRNA7 (R2 = 2.2%) and rs1881492 in CHRNG (R2 = 1.6%). Together, the 9 selected SNPs explain 4.9% of the phenotypic variation in the EA sample and 7.3% of the phenotypic variation in the AA sample.