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Chunk #25 — MATERIALS AND METHODS — Primary Outcome Variables and Data Analysis

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Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: influence of OPRM1 and dopamine transporter (SLC6A3) genes.
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The two primary outcome variables identified a priori were 1) drinking during the 5-day natural drinking period (based on TLFB collected on Day 6) and 2) number of drinks consumed after the standard/priming drink in the bar-lab on day 7. In order of importance based on our past work the secondary outcome variables were identified as the BAES stimulation and sedation scales after the priming drink, as well as the SHAS and AUQ scale scores after the priming drink.