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Chunk #84 — Practical application of microelectrode recordings — Using MEAs for neuroscience studies — MEAs and axonal signal tracking

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Revealing neuronal function through microelectrode array recordings.
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Axonal conduction was also measured by Zeck et al. (2011) from rabbit retina using HDMEAs. The authors were able to measure the velocity of axonal AP caused by stimuli and discovered that similar RGC types respond with the same latency and conduct with similar velocity (see Figure 12D). Except for the area where axons are myelinated, axonal signals were detected from all stimulated RGCs. This work also shows that when axons are very near or flat on the electrode array surface, it is possible to map the flow of APs. The axons do not necessarily need a tight contact on the electrodes, since the potential due to the APs was also detected from other surrounding electrodes, with lower amplitude compared to the electrode nearest the axon.