to confirm eQTL findings (For brain eQTLs, sample sizes ranged from 70–127). GeneMANIA Cytoscape 3.0.0 plugin (Mostafavi et al., 2008), a multiple association network integration algorithm for predicting gene function, was employed to identify genes in related gene networks; physical, co-expression, co-localization and pathway gene-gene interactions were evaluated. Once a gene network was identified (via GeneMANIA as described above), DAVID (Database for Annotation, Visualization, and Integrated Discovery; (Dennis et al., 2003) bioinformatics resource was used to assess gene functions common to this network. Functional Categories and Gene Ontologies were evaluated based on enrichment scores (Fisher Exact Probability Value or “EASE Score”) and tests of statistical significance, including p-values adjusted for multiple testing (Bonferonni correction).
