SNPs are usually mapped to genes based on physical distance[3], linkage disequilibrium (LD)[4], or a combination of both[5]. Genes are commonly assigned to pathways using well-established databases (such as Gene Ontology[6], KEGG[7], PANTHER[8], REACTOME[9], BIOCARTA[10]) or in-house annotation (based on co-expression[4], for example).
