With the newly added data, interactive visualizations and enhanced search capabilities, TCRD and Pharos in their current forms serve as IDG resources that facilitate better exploration of the dark and understudied regions of the human genome. The central idea of the resource continues to be enriching knowledge around human targets and monitoring their therapeutic development levels. One area that received significant attention in the current update is the search mechanism which was upgraded with the implementation of GraphQL API. To improve user interaction with the new API, example queries have been made available on the website. The TDL descriptions panel and the target expression anatomograms are the significantly improved components of the Pharos web interface. Further, most data that have been recently integrated into TCRD facilitate application of artificial intelligence/machine learning (AI/ML) techniques for target evaluation and drug repositioning (47), and are accessible in ML ready format. Most of the above described developments are based on the feedback obtained directly from the website visitors, several demo sessions and presentations at scientific meetings.
