in the same way. The results of our mapping method applied on the data from the source databases mentioned above are summarized in Table 1. Table 1.Database content and pairwise database overlaps in terms of matching physical entities and similar interactionsReactomeKeggHumancycPidBiocartaNetpathIntactDipMintHprdBiogridSpikeDatabase overlaps in terms of matching physical entitiesReactome6831103789356079624110673521217204117041506Kegg1037327114825938315225233291297540508Humancyc8931482389225368811055313870116561065947Pid560592533614764354799371886135712631027Biocarta79638368876433873028923921011169514771346Netpath24115110354302739392173450615568479Intact106722555379989239241385762660354630163237Dip35223138371392173576964637865828707Mint1217329701886101145026606375849468439393915Hprd20411297165613571695615354686546841016571855973Biogrid170454010651263147756830168283939718586965248Spike15065089471027134647932377073915597352487012Database overlaps in terms of similar interactionsReactome41292621221018034973151304212118Kegg2621655213040000000Humancyc1222131322020122742Pid10100351026496634673333243186Biocarta8042264222167513543139114173Netpath3400966719155734123821510224Intact970163515768803122714321615834080Dip31024635343121218389821656418Mint51027343123271438913187721144285676Hprd3040733313982132168217211379551946311351Biogrid2120424311451015836564428194632803810303Spike1180218617322440804185676113511030322232Current versions of the integrated databases are: Reactome 25, KEGG 47.0, HumanCyc 12.1, PID 2008_06_10, BioCarta 2008_01_08, NetPath downloaded on 6.7.2008, IntAct 2008-06-27, DIP 2008-01-13, MINT 2008-05-19, HPRD I_090107, BioGRID 2.0.42 and SPIKE downloaded on 6.7.2008.
