The overall prediction accuracy of the trans-ancestry PRS in the Hispanic/Latino group was between that observed in the European and African individuals: variance explained = 8.0%; covariates-adjusted AUC = 0.63; OR/SD = 2.08 (Table 2; Additional File 2: Table S3), reflecting that the Hispanic/Latino population is a recent admixture among Europeans, Africans, and Native Americans. Hispanic individuals with high PRS had a substantially increased risk of T2D, with an OR of 6.87 (95% CI: 3.11–15.15; P value = 1.81E−06) when contrasting the top 2% of the PRS with the remaining 98% of the distribution (Table 2; Additional File 2: Table S3). However, we note that due to the relatively small sample size of the Hispanic/Latino sample in the eMERGE study, the OR estimates for the tails of the PRS distribution were associated with large uncertainties.
