AnnoTatOR) method to study the significance of pathways. Although this method corrects variable gene sizes by simulations, it requires a pre-determined P-value cutoff for selecting significant SNPs and the evaluation of pathways is gene-based, not SNP-based. Yu et al. [18] used an adjusted P-value for each gene, and also treated gene as the basic unit for analysis. Since the gene-based approaches focused on testing significance at the gene-level, they may have low power to detect pathways containing only a few genes[19].
