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Chunk #51 — Materials and Methods — Meta-Analysis Gene-set Enrichment of variaNT Associations (MAGENTA) — Steps 2 and 3: Scoring genes based on SNP association scores and correcting for confounders

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Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.
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For each gene g in the genome we calculated a score, that is the probability that the gene is associated with a given disease or trait. In computing this score we corrected for the confounding effects of physical and genetic properties of genes on the gene p-value.