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Chunk #36 — Results — Testing for main and interaction effects of MAOA genotype and childhood adversity on risk for CD

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Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females.
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After ridit transformation, a significant main effect of the low-activity MAOA allele on CD remained (b = 0.46, odds ratio (OR) 1.58, 95% confidence interval (CI) 1.01-2.48, p = 0.05) and G × E was non-significant (β=−0.25, OR 0.78, 95% CI 0.57-1.07, p = 0.12). Thus, there is evidence for a weak main effect of MAOA genotype on CD in females. Furthermore, the effects of childhood adversity (β = 0.58, OR 1.78, 95% CI 1.13-1.93, p = 0.0006) and maternal ASP (β = 0.47, OR 1.60, 95% CI 0.99-1.86, p = 0.006) on CD remained significant after ridit transformation. However, significant G × E associated with CD was no longer present.