of serine/threonine protein kinases and has a role in normal cell division. It is expressed in multiple regions of the brain (GTEx). Two studies have reported that PLK2 expression is significantly upregulated in human Alzheimer’s disease brain tissue (Mbefo et al., 2010, Lee et al., 2019). Polymorphisms in PLK2 are associated with Alzheimer’s disease (Bufill et al., 2015), and it has been suggested as an attractive novel target for Alzheimer’s disease drug therapy (Lee et al., 2019, Lee et al., 2017).
