Chunk #49 — DISCUSSION — Cellular mechanisms associated with trafficking of GluR1-containing AMPARs toward synaptic junctions

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Endogenous GluR1-containing AMPA receptors translocate to asymmetric synapses in the lateral amygdala during the early phase of fear memory formation: an electron microscopic immunocytochemical study.

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The increase in the number of spines immunoreactive for the two F-actin binding proteins, profilin (Lamprecht et al., 2006a) and spinofilin (Radley et al., 2006), within the LA was detected by using an approach similar to ours. Of the two, the increase of spinophilin-immunoreactive spines was observed 24 hours after fear conditioning, e.g., during the period that is sensitive to protein synthesis inhibitors and after STM is converted to LTM. Because these events extend beyond the time point that we measured, the mechanisms underlying the increased GluR1-containing AMPAR that we observed may not have interacted with the mechanisms underlying the increase of spinophilin in the LA.