overall correlated reasonably well with cis-association significance (Figure S4) but the heritability estimates have large variance and are to be taken with caution on a per gene basis. When evaluated in the context of GO-slim terms, we detected a significant deficit of genes involved in “cellular processes” among the set of genes with significant cis- associations. This is not surprising since segregating genetic variation affecting such basic cell functions would be expected to be detrimental.
