ADH1B shows enzymatic activities besides those related to ethanol. According to the HumanCyc database (available at http://humancyc.org/; [Romero and others 2005]), ADH1B catalyzes 19 different reactions interacting with different substrates and cofactors (Table 2). Considering multiple databases (i.e., Biosystems [Geer and others 2010], Reactome [Fabregat and others 2016], PharmGKB [Whirl-Carrillo and others 2012], KEGG [Kanehisa and others 2016]), ADH1B is reported to be involved in the metabolic pathways of many compounds besides ethanol, including fatty acids, acetone, epinephrine, glucose, retinol, tyrosine, tryptophan, ifosfamide, cyclophosphamide, abacavir, and celecoxib; and notably, neurotransmitters serotonin and norepinephrine (Supplemental Table 4). To understand further the interaction of ADH1B with other proteins and the related molecular mechanisms, we investigated the STRING v.10.0 database (available at http://string-db.org/; [Kanehisa and others 2016]) considering interaction score > 0.9 (highest confidence) and excluding textmining from the interaction sources. We observed that ADH1B shows highest-confidence interactions with 18 known proteins (Figure 5; Supplemental Table 5). We then conducted a Gene Ontology (GO) enrichment analysis considering the ADH1B protein interactive network, and observed 10 significant GO results (FDR < 5%; Supplemental Table
