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Chunk #4 — 1. Introduction

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Random Forest Classification of Alcohol Use Disorder Using fMRI Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures.
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The DMN, which is a functional network representing the ongoing mental processes during resting state, primarily involves basic neural activity underlying self-referential thought, mentation, and introspection [50], and recent studies have reported aberrant DMN connectivity in AUD [10,45,47]. In a study using fMRI FC to examine several resting state networks, including the DMN, Zhu et al. [11] reported that the RF method successfully classified AUD from control subjects both within and between networks. It is important to relate network dynamics to corresponding neuropsychological functions and behavioral outcomes, such as impulsivity, which are characteristic features in AUD [3,51,52]. For example, it is well-established that individuals with AUD manifest neuropsychological impairments in executive functioning, memory, and visuospatial processing [3,53,54,55,56], and studies have also demonstrated that AUD was associated heightened impulsivity [34,57]. Furthermore, all three domains are related among each other in the development and maintenance of alcohol addiction [58,59]. For instance, impulsivity observed in addicted individuals may result from a failure or dysfunction of the executive system and both domains may underlie distinct yet interactive brain systems [60]. Therefore, it is essential