Another interesting observation of the present study was the association of glutamatergic markers with aging. In addition to demonstrating a decline of GluA1 with age that has been observed in the hippocampus in rats (49), the current findings document for the first time an age-related decline in regard to the interaction between dynamin-3 and Homer 1b/c. Such impairment of the PSD and the coupling to the endocytic zone would be consistent with the known reduction of synaptic plasticity and concomitant deficit in learning and memory as seen during normal aging (50, 51).
