A number of structurally different sEHIs attenuate both allodynia and thermal hyperalgesia under these conditions and the anti-nociceptive effects are highly correlated with increases in EFAs brought about by sEH inhibition [34]. These effects are dose dependent and are comparable to the effects of a moderate dose of morphine (1 mg/kg), though some sEHIs have long half-lives and are effective for a much longer period [22].
