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Chunk #42 — DISCUSSION AND POLICY IMPLICATIONS

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Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.
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focused on a single gene, the glucocorticoid receptor NR3C1. We expect there are dozens, if not hundreds of genes and intergenic loci involved in regulating response to Fast Track and other complex behavioral interventions. Ultimately, genome-wide investigations of variants moderating intervention effects will be needed to uncover genetic signatures of intervention response that can be used to match individuals to interventions. Our study provides proof of concept to motivate the development of databases capable of supporting genome-wide inquiry.