Second, P300 potential recorded at frontal scalp sites represents orienting response, while P300 recorded at parietal scalp sites represents the match process between the incoming stimulus and the voluntarily maintained attentional trace of the task relevant stimulus. However, little attempt has ever been made to compare P300 potential between frontal and tempo-parietal brain regions in psychiatric patients. In this context, we aimed to compare dipole P300 activity between these regions and determine whether depressive and anxiety disorder could be differentiated.