Similar to FAM53B, the meta-analysis result for rs2005290–a SNP located in a cluster of olfactory receptor genes, between OR3A1 and OR3A2 and about 8 kb from each–is supported by evidence in both populations (p=4.47×10−7). It may be relevant to this finding implicating olfaction that variation in a taste receptor gene was previously associated with alcohol dependence.28 Further, these genes have a structure similar to that of neurotransmitter and hormone receptors.
