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Chunk #17 — Methods — Preprocessing

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Differentiating the Effects of Familial Risk for Alcohol Dependence and Prenatal Exposure to Alcohol on Offspring Brain Morphology.
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The resulting SPM contrasts maps were thresholded with p<0.005 with a cluster size of 200 voxels. The significance of these thresholded clusters was determined using a family wise error (FWE) correction threshold which was set at p=0.05. Additionally, regional volumes were calculated using the MarsBaR ROI toolbox (http://marsbar.sourceforge.net) to compare the gray matter (GM) volume of the specified regions of interest (ROIs) which were further compared in SPSS (version 20). ROIs were calculated for each participant and entered into SPSS analyses along with multiple covariates to follow up on areas revealed in the whole brain analyses.