We found a significantly lower global gamma/theta CFC in pMCI compared with sMCI (p-value = 0.004, t-value = −11.09; see Figure 1). After adjusting for multiple comparisons using false discovery rate, no significant differences in the electrode-to-electrode comparisons between pMCI and sMCI were found. The strongest correlation was found between ACE and gamma/theta CFC (p-value = 0.030, rho = 0.527; see Figure 2 for the scatterplot). No significant correlations were found between gamma/theta CFC and amyloid (p-value = 0.971, rho = 0.010), total tau (p-value = 0.592, rho = −0.151), or phosphorylated tau (p-value = 0.824, rho = −0.060) in MCI. Since total tau is a marker for neurodegeneration and found to be related to progression from MCI to AD (Diniz et al., 2008), we investigated the partial correlation between ACE and total tau in patients with MCI, which was not significant (p-value = 0.107, rho = −0.449).
